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NEWS! GrayMatters Health Announces Appointment of Five Expert Advisors including Patrick J. Kennedy, Owen Scott Muir MD, Linda Carpenter MD, Kenneth Pages MD, and Ali A Farooqui MD.

Prism
Powered by the Brain.

An interventional psychiatry suite of solutions powered by
fMRI-informed digital biomarkers for personalized patient care. 

GrayMatters Health is leading a transformation - bringing evidence-based, accessible technology to psychiatry clinics to augment standard-of-care therapies and help improve patient outcomes and patient lives.

 

With a strong foundation in scientific research, Prism self-neuromodulation is being used in clinical practice to help patients get Back to Better™. This innovation enables patients to learn to regulate brain activity associated with their mental health condition in the clinic, gaining a skill for use in their daily lives.  

 

Prism is a comprehensive suite of solutions for scientifically leveraging the power of the brain, featuring protocols for PTSD and Depression.  

 

PTSD

Prism uses an amygdala-based biomarker and engaging computer simulation to help improve symptoms of post-traumatic stress disorder (PTSD). Read the outcomes of our clinical study. 

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Depression

Patients learn to up-regulate the reward-system biomarker (Ventral Striatum based) to help live better with depression. ​​Review the results of the pilot study on anhedonia. 

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Value for your patients and your practice

Leading-edge technology

The ground-breaking fMRI-Informed digital biomarkers that power Prism have a strong scientific and clinical foundation. The PTSD protocol uses an amygdala-based biomarker and the Depression protocol uses a reward-system biomarker. Learn more >>

Operational simplicity

Prism integrates seamlessly with operational flow from intake to treatment and can be stored on a shelf or in a drawer when not in use or when administering other interventions. Most importantly, Prism sessions can be administered by a technician to optimize clinician time. 
Read a
Case Study of a clinic in Texas.

Personalized care

Prism reads the signal from sensors on the EEG cap and computes the relevant digital biomarker. These signals are the result of mental strategies the patient explores – this is as personal as a treatment can get. Watch the Prism PTSD mental strategy animation on YouTube.

With you every step of the way

GMH provides onsite installation and training as well as in-person and remote support. It doesn't stop there...Ask about our Prism Pathway to build a successful Prism program.

 

 

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Impact on
Patients

"Since using Prism, my quality of life has improved and my capacity to enjoy life has really opened up! I feel calmer, more in control, and am thinking more clearly.”
Prism Patient

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© 2026 GrayMatters Health. All Rights Reserved.

Disclaimer: The information on this website is not intended to be a substitute for professional medical advice. Always discuss treatment options and treatment outcomes with your physician or other qualified mental health provider.​

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