Amygdala EFP Neurofeedback Effects on PTSD Symptom Clusters and Emotional Regulation Processes

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/ Goldental N, Gross R, Amital D, Harel EV, Hendler T, Tendler A,  Levi L, Lavro D, Harmelech T, Grinapol S, Nacasch N, Fruchter E.
Journal of Clinical Medicine. 2025; 14(7):2421. 

 

Post-traumatic stress disorder (PTSD) manifests through distinct symptom clusters that can respond differently to treatments.

 

Self-neuromodulation guided by the Amygdala-derived EFP has been utilized to train PTSD patients to regulate amygdala-related activity and decrease symptoms. 
A combined analysis of 128 PTSD patients from three clinical trials of Amygdala-derived EFP self-neuromodulation was done to evaluate effects across symptom clusters (as assessed by CAPS-5 subscales) and on emotion regulation processing (evaluated by the ERQ). 

Amygdala-derived EFP self-neuromodulation significantly reduced severity across all PTSD symptom clusters immediately post-treatment, with improvements maintained at three-month follow-up. The arousal and reactivity cluster showed continued significant improvement during follow-up. Combined effect sizes were large (η2p = 0.23–0.35) across all symptom clusters. Regression analysis revealed that emotion regulation processes significantly explained 17% of the variance in symptom improvement during the follow-up period. 

Amygdala-derived EFP self-neuromodulation demonstrated a reduction of PTSD symptoms across all symptom clusters with benefits continuing after treatment completion.

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To read the full article on Journal of Clinical Medicine - https://www.mdpi.com/2077-0383/14/7/2421