Knowledge Center
GrayMatters Health clinical foundation and core technology have been extensively researched with peer-reviewed articles in prestigious medical journals.
Resources
January 2026
BLOG: Amygdala-Based Self-Neuromodulation for Treating Dissociative Symptoms of PTSD
/ Aron Tendler, MD
January 2026
BLOG: Prism Self-Neuromodulation as a Cost-Effective Adjunct PTSD Treatment
/ Aron Tendler, MD
November 2025
CASE STUDY: Real world outcomes with Prism™ at the Institute for Advanced Psychiatry
/ Diana Ghelber, MD and Pam Schwartz
Clinical
06 October 2025
Amygdala-targeted neurofeedback for dissociative symptoms in PTSD: Converging evidence from three independent studies
/ Harmelech T, Hendler T, Gurevitch G, Fine N, Fruchter E, Amital D, Goldental N, Gross R, Robinson MA, Lebois LAM, Kaufman M, Tendler A. Psychiatry Research Volume 353, November 2025, 116752.
23 September 2025
Cost Effectiveness of Adjunctive Neurofeedback vs. Psychotherapy or Pharmacotherapy for Post-Traumatic Stress Disorder
/ Voigt JD, Tendler A, Marci C, Carpenter LL. Healthcare 2025, 13(19), 238.
17 April 2025
Targeted limbic self-neuromodulation for alleviating central sensitization symptoms in fibromyalgia
/ Or-Borichev A, Lerner Y, Hamrani Y, Gurevitch G, Mor N, Doron M, Sarna N, Ablin JN, Hendler T, Sharon H. (2025) BMC Med 23, 304.
17 April 2025
Reward System EEG–fMRI Pattern Neurofeedback for Major Depressive Disorder with Anhedonia: A Multicenter Pilot Study
/ Amital D, Gross R, Goldental N, Fruchter E, Yaron-Wachtel H, Tendler A, Stern Y, Deutsch L, Voigt J.D., Hendler T, Harmelech T, Singer N, Sharon H. Brain Sci. 2025, 15, 476.
2 April 2025
Amygdala EFP Neurofeedback Effects on PTSD Symptom Clusters and Emotional Regulation Processes
/ Goldental N, Gross R, Amital D, Harel EV, Hendler T, Tendler A, Levi L, Lavro D, Harmelech T, Grinapol S, Nacasch N, Fruchter E. Journal of Clinical Medicine. 2025; 14(7):2421.
12 March 2025
Can Amygdala-Derived-EEG-fMRI-Pattern (EFP) Neurofeedback Treat Sleep Disturbances in PTSD?
/ Tendler A, Stern Y, Harmelech T.
Brain Sciences. 2025; 15(3):297.
March 2024
Systematic review and meta-analysis of neurofeedback and its effect on posttraumatic stress disorder
/ Voigt JD, Mosier M, Tendler A. Front. Psychiatry 15:1323485.
2 March 2024
Amygdala-derived-EEG-fMRI-pattern neurofeedback for the treatment of chronic post-traumatic stress disorder. A prospective, multicenter, multinational study evaluating clinical efficacy.
/ Fruchter E, Goldenthal N, Adler LA, Gross R, Harel EV, Deutsch L, Nacasch N, Grinapol S, Amital D, Voigt JD, Marmar CR. Psychiatry Research, Volume 333, 2024.
28 December 2023
Pilot Study of Prism EFP NeuroFeedback in Adult ADHD
/ Adler, L. A., Anbarasan, D., Leon, T., Sardoff, T., Descorbeth, O., Cho, D., Stern, Y., Kraft, O., Hendler, T., & Marmar, C. R. Journal of Attention Disorders, 28(5), 905-912
24 August 2023
Amygdala-related EEG Neuro-Feedback as an add-on Therapy for treatment-resistant Childhood Sexual Abuse PTSD: Feasibility Study
/ Fine NB, Helpman L, Bardin Armon D, Gurevitch G, Sheppes G, Seligman Z, Hendler T, Bloch M.
Psychiatry Clin Neurosci 2023 Aug 24.
24 June 2023
Integration of limbic self-neuromodulation with psychotherapy for complex post-traumatic stress disorder: treatment rationale and case study
/ Fine NB, Neuman Fligelman E, Carlton N, Bloch M, Hendler T, Helpman L, Seligman Z, Armon DB (2024). European Journal of Psychotraumatology, 15(1).
24 June 2023
Limbic self-neuromodulation as a novel treatment option for emotional dysregulation in premenstrual dysphoric disorder (PMDD); a Proof-of-concept study
/ Tene O, Cohen MB, Helpman L, Fine N, Halevy, A, Goldway N, Perry D, Bary P, Aisenberg Romano G, Ben-Zion Z, Hendler T, Block M. Psychiatry and Clinical Neurosciences 77: 550–558, 2023
24 May 2022
Volitional limbic neuromodulation exerts a beneficial clinical effect on Fibromyalgia.
/ Goldway N, Ablin J, Lubin O, Zamir Y, Keynan JN, Or-Borichev A, Cavazza M, Charles F, Intrator N, Brill S, Ben-Simon E, Sharon H, Hendler T. NeuroImage 186 (2019) 758–770
15 October 2021
Amygdala electrical-finger-print (AmygEFP) NeuroFeedback guided by individually-tailored Trauma script for post-traumatic stress disorder: Proof-of-concept.
/ Fruchtman-Steinbok T, Keynan JN, Cohen A, Jaljuli I, Mermelstein S, Drori G, Routledge E, Krasnoshtein M, Playle R, Linden DEJ, Hendler T.
Neuroimage Clin. 2021;32:102859.
10 December 2018
Electrical fingerprint of the amygdala guides neurofeedback training for stress resilience.
/ Keynan JN, Cohen A, Jackont G, Green N, Goldway N, Davidov A, Meir-Hasson Y, Raz G, Intrator N, Fruchter E, Ginat K, Laska E, Cavazza M, Hendler T. Nat Hum Behav. 2019 Jan;3(1):63-73.
EEG-fMRI Pattern (EFP) Biomarkers
/ Brandman T, Stern Y, Gurevitch G, Harmelech T, Shoval G, Kraft O, Tendler A, Hendler T. Molecular Psychiatry (2025).
October 2024
Amygdala self-neuromodulation capacity as a window for process-related network recruitment
/ Gurevitch G, Lubianiker N, Markovits T, Or-Borichev A, Sharon H, Fine NB, Fruchtman-Steinbok T, Keynan JN, Shahar M, Friedman A, Singer N. Philosophical Transactions B. 2024 Oct 21;379(1915):20240186.
March 2024
Development and validation of an fMRI-informed EEG model of reward-related ventral striatum activation
/ Singer N, Poker G, Dunsky-Moran N, Nemni S, Reznik Balter S, Doron M, Baker T, Dagher A, Zatorre RJ, Hendler T.
NeuroImage 276 (2023) 120183.
22 December 2023
/ Zopfs M, Jindrová M, Gurevitch G, Keynan JN, Hendler T, Baumeister S, Aggensteiner PM, Cornelisse S, Brandeis D, Schmahl C, Paret C. Psychological Medicine. 2024;54(8):1651-1660.
24 May 2022
Feasibility and utility of amygdala neurofeedback
/ Goldway N, Jalon I, Keynan JN, Hellrung L, Horstmann A, Paret C, Hendler T. Neurosci Biobehav Rev. 2022 Jul;138:104694.
19 April 2019
Process-based framework for precise neuromodulation
/ Lubianiker N, Goldway N, Fruchtman-Steinbok T, Paret C, Keynan JN, Singer N, Cohen A, Kadosh KC, Linden DEJ, Hendler T.Nat Hum Behav. 2019 May;3(5):436-445
16 May 2016
Multi-modal Virtual Scenario Enhances Neurofeedback Learning
/ Cohen A, Keynan JN, Jackont G, Green N, Rashap I, Shani O, Charles F, Cavazza M, Hendler T, Raz G.
Front Robot AI, 2016 Aug 31; 3:52.
6 January 2016
/ Keynan JN, Meir-Hasson Y, Gilam G, Cohen A, Jackont G, Kinreich S, Ikar L, Or-Borichev A, Etkin A, Gyurak A, Klovatch I, Intrator N, Hendler T.Biol Psychiatry. 2016 Sep 15;80(6):490-496
16 May 2016
One-Class fMRI-Inspired EEG Model for Self-Regulation Training
/ Meir-Hasson Y, Keynan JN, Kinreich S, Jackont G, Cohen A, Podlipsky-Klovatch I, Hendler T, Intrator N.PLoS One. 2016 May 10;11(5):e0154968.
15 November 2013
An EEG Finger-Print of fMRI deep regional activation
/ Meir-Hasson Y, Kinreich S, Podlipsky I, Hendler T, Intrator N.
Neuroimage. 2014 Nov 15;102 Pt 1:128-141.